By Serena McNiff
Whereas it is not clear exactly how SARS-CoV-2 causes clots, a brand new research means that the quantity of a selected protein — referred to as issue V — in a affected person’s blood could have one thing to do with it.
In March, researchers at Massachusetts Normal Hospital obtained a blood pattern from a affected person with extreme COVID-19 and observed one thing uncommon. The affected person’s blood had considerably above-normal ranges of issue V.
Researchers then studied greater than 100 sufferers handled within the intensive care unit for COVID-19.
Excessive ranges of issue V had been discovered throughout the group, and almost half of the sufferers had above-normal ranges. When researchers in contrast the samples to historic information, greater than 1 in 10 sufferers had larger issue V ranges than had been seen earlier than on the hospital.
“Other than COVID-19, I’ve by no means seen anything trigger markedly elevated issue V, and I have been doing this for 25 years,” research co-author Dr. Elizabeth Van Cott mentioned in a hospital information launch. She is a pathology investigator at Mass Normal and a pathology professor at Harvard Medical Faculty.
The research discovered that sufferers with elevated issue V had been extra prone to have blood clots within the lungs, referred to as pulmonary embolism, and deep vein thrombosis (DVT), or clots within the veins.
Of sufferers with excessive ranges of issue V, one-third had both DVT or a pulmonary embolism, in contrast with 13% of sufferers with decrease ranges.
Whereas sufferers with excessive issue V ranges had been at higher threat for clotting issues, sufferers with decrease issue V ranges had a better threat of demise, researchers discovered.
A lower in issue V ranges may point out sufferers are progressing to a critical and infrequently deadly situation during which clotting processes turn out to be overactive, Van Cott and colleagues mentioned.
They mentioned the findings may assist determine which sufferers are at elevated threat of blood clots and demise.
The findings had been not too long ago printed on-line within the American Journal of Hematology.